Vancomycin cefotaxime penetration
Cefotaxime is an extended-spectrum cephalosporin that has a spectrum of . Vancomycin penetration into CSF during meningitis can be unpredictable, and.
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Description:Since concentrations in microdialysates and abscesses are not frequently available for humans, this review focuses on drug CSF concentrations. When several equally active compounds are available, a drug which comes close to these physicochemical and pharmacokinetic properties should be preferred. In many cases, however, pharmacokinetics have to be balanced against in vitro activity. Direct injection of drugs, which do not readily penetrate into the CNS, into the ventricular or lumbar CSF is indicated when other effective therapeutic options are unavailable. This is particularly true for infections caused by penicillin-resistant pneumococci, methicillin-resistant staphylococci, multiresistant Gram-negative aerobic bacilli, or several other organisms including Aspergillus spp.
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